Research

Exploring cellular mechanisms and developing novel therapeutic strategies for human diseases.

Highlighted

TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function

Si-Yi Chen, Tao Yue, Qian Lei, An-Yuan Guo

Nucleic Acids Research  ·  29 Sep 2020  ·  10.1093/nar/gkaa796

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2026

Longitudinal profiling of serum ADAM17 across clinical stages in multiple myeloma: a dynamic biomarker and its association with T cell alterations

Jiao Qu, Yancheng Li, Chenchen Li, Di Wu, Yulin Cao, Shumei Xiao, Xingshuo Bao, Qiubai Li, Zhichao Chen, Lei Chen

Frontiers in Molecular Biosciences  ·  30 Jan 2026  ·  10.3389/fmolb.2026.1768193

2025

Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin-Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Pathway

Yi Zhong, Di Fan, Peiyi Zhang, Xiaoxiang Mao, Baoqing Liu, Cheng Wang, Qiubai Li

Journal of the American Heart Association  ·  19 Aug 2025  ·  10.1161/JAHA.125.041440

Targeting capacity, safety and efficacy of engineered extracellular vesicles delivered by transdermal microneedles to treat plasmacytoma in mice

Yulin Cao, Xuan Hu, Di Wu, Yuxuan Jiang, Yali Yu, …, Hongxiang Wang, Yong Deng, Lei Chen, Zhichao Chen, Qiubai Li

Clinical and Translational Medicine  ·  02 May 2025  ·  10.1002/ctm2.70327

Extracellular Vesicles: A Review of Their Therapeutic Potentials, Sources, Biodistribution, and Administration Routes

Xiaorong Su, Hongxiang Wang, Qiubai Li, Zhichao Chen

International Journal of Nanomedicine  ·  13 Mar 2025  ·  10.2147/IJN.S502591

2024

Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders

Anyuan Zhang, Qiubai Li, Zhichao Chen

International Journal of Molecular Sciences  ·  30 Dec 2024  ·  10.3390/ijms26010225

Antisenescence Expansion of Mesenchymal Stem Cells Using Piezoelectric β-Poly(vinylidene fluoride) Film-Based Culture

Liuyue Xu, Wenxiang Ren, Yaoying Long, Bianlei Yang, Li Chen, …, Hongxiang Wang, Ting Chen, Guifen Fan, Qiubai Li, Zhichao Chen

ACS Applied Materials & Interfaces  ·  20 Nov 2024  ·  10.1021/acsami.4c12725

Therapeutically Harnessing Tumor Cell-Derived Extracellular Vesicles for Multiple Myeloma: Recent Advances and Future Perspectives

Shumei Xiao, Lei Chen, Zhichao Chen, Qiubai Li

Pharmaceutics  ·  11 Nov 2024  ·  10.3390/pharmaceutics16111439

Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner

Bian-lei Yang, Yao-ying Long, Qian Lei, Fei Gao, Wen-xiang Ren, …, An-yuan Zhang, Shan Wang, Hong-xiang Wang, Zhi-chao Chen, Qiu-bai Li

Acta Pharmacologica Sinica  ·  24 Jun 2024  ·  10.1038/s41401-024-01327-3

Targeting Senescent Alveolar Epithelial Cells Using Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles To Treat Pulmonary Fibrosis

Yaoying Long, Bianlei Yang, Qian Lei, Fei Gao, Li Chen, …, Weiqun Chen, Hongxiang Wang, Ting Chen, Zhichao Chen, Qiubai Li

ACS Nano  ·  21 Feb 2024  ·  10.1021/acsnano.3c10547

2023

Procoagulant Properties of Mesenchymal Stem Cells and Extracellular Vesicles: A Novel Aspect of Thrombosis Pathogenesis

Bianlei Yang, Yaoying Long, Anyuan Zhang, Hongxiang Wang, Zhichao Chen, Qiubai Li

Stem Cells  ·  15 Nov 2023  ·  10.1093/stmcls/sxad087

Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199

Wen-xiang Ren, Hao Guo, Sheng-yan Lin, Si-yi Chen, Yao-ying Long, …, Shan Wang, Yi-cheng Zhang, Ke-shu Zhou, Zhi-chao Chen, Qiu-bai Li

Acta Pharmacologica Sinica  ·  29 Aug 2023  ·  10.1038/s41401-023-01142-2

2022

The transplantation of rapamycin-treated senescent human mesenchymal stem cells with enhanced proangiogenic activity promotes neovascularization and ischemic limb salvage in mice

Yu-lin Cao, Wen-lan Chen, Qian Lei, Fei Gao, Wen-xiang Ren, Li Chen, Hong-xiang Wang, Ting Chen, Qiu-bai Li, Zhi-chao Chen

Acta Pharmacologica Sinica  ·  01 Apr 2022  ·  10.1038/s41401-022-00896-5

2021

Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

Qian Lei, Fei Gao, Teng Liu, Wenxiang Ren, Li Chen, …, Hongxiang Wang, Zhichao Chen, Qiubai Li, Yu Hu, An-Yuan Guo

Science Translational Medicine  ·  27 Jan 2021  ·  10.1126/scitranslmed.aaz8697

2020

TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function

Si-Yi Chen, Tao Yue, Qian Lei, An-Yuan Guo

Nucleic Acids Research  ·  29 Sep 2020  ·  10.1093/nar/gkaa796

A 6-Membrane Protein Gene score for prognostic prediction of cytogenetically normal acute myeloid leukemia in multiple cohorts

Sheng-Yan Lin, Ya-Ru Miao, Fei-Fei Hu, Hui Hu, Qiong Zhang, Qiubai Li, Zhichao Chen, An-Yuan Guo

Journal of Cancer  ·  01 Jan 2020  ·  10.7150/jca.35382

2019

Identification of STAB1 in Multiple Datasets as a Prognostic Factor for Cytogenetically Normal AML: Mechanism and Drug Indications

Sheng-Yan Lin, Fei-Fei Hu, Ya-Ru Miao, Hui Hu, Qian Lei, Qiong Zhang, Qiubai Li, Hongxiang Wang, Zhichao Chen, An-Yuan Guo

Molecular Therapy Nucleic Acids  ·  01 Dec 2019  ·  10.1016/j.omtn.2019.09.014

Tumor-derived extracellular vesicles inhibit osteogenesis and exacerbate myeloma bone disease

Liming Zhang, Qian Lei, Hongxiang Wang, Cuiwei Xu, Teng Liu, …, Fenfen Fu, Guolin Yuan, Zhichao Chen, An-Yuan Guo, Qiubai Li

Theranostics  ·  01 Jan 2019  ·  10.7150/thno.27550

2018

EVmiRNA: a database of miRNA profiling in extracellular vesicles

Teng Liu, Qiong Zhang, Jiankun Zhang, Chao Li, Ya-Ru Miao, Qian Lei, Qiubai Li, An-Yuan Guo

Nucleic Acids Research  ·  18 Oct 2018  ·  10.1093/nar/gky985

Enhanced Response of Acute Monocytic Leukemia Cells to Low-dose Cytarabine by 1,25-dihydroxyvitamin D3

Hao Guo, Sheng-yan Lin, Wen-xiang Ren, Qian Lei, Zhi-chao Chen, Lu Zhang, Qiu-bai Li

Current Medical Science  ·  01 Feb 2018  ·  10.1007/s11596-018-1838-9

2017

BCR-ABL1-positive microvesicles malignantly transform human bone marrow mesenchymal stem cells in vitro

Fen-fen Fu, Xiao-jian Zhu, Hong-xiang Wang, Li-ming Zhang, Guo-lin Yuan, Zhi-chao Chen, Qiu-bai Li

Acta Pharmacologica Sinica  ·  24 Aug 2017  ·  10.1038/aps.2017.116

Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities

Hui Xie, Zhenxing Wang, Liming Zhang, Qian Lei, Aiqi Zhao, Hongxiang Wang, Qiubai Li, Yilin Cao, Wen Jie Zhang, Zhichao Chen

Scientific Reports  ·  03 Apr 2017  ·  10.1038/srep45622

Tumor Cell-Derived Microvesicles Induced Not Epithelial-Mesenchymal Transition but Apoptosis in Human Proximal Tubular (HK-2) Cells: Implications for Renal Impairment in Multiple Myeloma

Aiqi Zhao, Fancong Kong, Chun-Jie Liu, Guoxin Yan, Fei Gao, Hao Guo, An-Yuan Guo, Zhichao Chen, Qiubai Li

International Journal of Molecular Sciences  ·  27 Feb 2017  ·  10.3390/ijms18030513

Microvesicles as Potential Biomarkers for the Identification of Senescence in Human Mesenchymal Stem Cells

Qian Lei, Teng Liu, Fei Gao, Hui Xie, Li Sun, …, Liming Zhang, Hongxiang Wang, Zhichao Chen, An-Yuan Guo, Qiubai Li

Theranostics  ·  01 Jan 2017  ·  10.7150/thno.18915

2016

Prognostic Significance of KIT Mutations in Core-Binding Factor Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis

Wenlan Chen, Hui Xie, Hongxiang Wang, Li Chen, Yi Sun, Zhichao Chen, Qiubai Li

PLOS ONE  ·  15 Jan 2016  ·  10.1371/journal.pone.0146614

Mesenchymal Stem Cell‐Derived Microvesicles Support Ex Vivo Expansion of Cord Blood‐Derived CD34⁺ Cells

Hui Xie, Li Sun, Liming Zhang, Teng Liu, Li Chen, …, Ping Zou, Qiubai Li, An-yuan Guo, Zhichao Chen, Hongxiang Wang

Stem Cells International  ·  01 Jan 2016  ·  10.1155/2016/6493241

2013

Serum deprivation elevates the levels of microvesicles with different size distributions and selectively enriched proteins in human myeloma cells in vitro

Li Sun, Hong-xiang Wang, Xiao-jian Zhu, Pin-hui Wu, Wei-qun Chen, Ping Zou, Qiu-bai Li, Zhi-chao Chen

Acta Pharmacologica Sinica  ·  30 Dec 2013  ·  10.1038/aps.2013.166

Microvesicles secreted from human multiple myeloma cells promote angiogenesis

Yan Liu, Xiao-jian Zhu, Chen Zeng, Pin-hui Wu, Hong-xiang Wang, Zhi-chao Chen, Qiu-bai Li

Acta Pharmacologica Sinica  ·  30 Dec 2013  ·  10.1038/aps.2013.141